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TECHNOLOGY

Product Pipeline

Neuraptive is advancing a pipeline of investigational therapies and technologies for peripheral nerve injury.

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NTX-001 | PEG-Fusion

Phase 3 Clinical Development

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NTX-002 | Bioresorbable Nerve Stimulation

Preclinical Development

NTX-001

A novel nerve fusion system for repairing severed peripheral nerves.

 

NTX-001 is a kit comprised of nerve fusion technology and a specialized device intended for use during surgical nerve procedures.

 

The technology in our kit is designed to restore electrical signaling across a severed peripheral nerve intra-operatively, thus preventing Wallerian degeneration in axons distal to injury.​

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NTX-001 is investigational and has not been approved or cleared by the FDA. Its safety and effectiveness in humans have not been established.

NTX-002
Bioresorbable Nerve Stimulation

An investigational bioresorbable wireless nerve stimulation device for peripheral nerve injury.

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NTX-002 is in preclinical development for transected nerves and crush injuries.

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The device is designed to deliver targeted electrical stimulation to an injured nerve and to resorb over time, so that surgical support nerve regeneration so that surgical removal is not required.

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NTX-002 is investigational and has not been approved or cleared by the FDA. Its safety and effectiveness in humans have not been established.

PEG-FUSION PROTOCOL

NTX-001, utilizing PEG-fusion, is a treatment under investigation in which a sequence of reagents, including polyethylene glycol (PEG), is applied during surgical nerve repair. The approach is designed to promote fusion of axonal membranes to restore axonal continuity after severance.

NEURORRHAPHY

no͝o-rôr ′ ə-fē
Neurorrhaphy is the surgical suturing of a divided nerve. 

WALLERIAN DEGENERATION

Wallerian degeneration is the natural process in which the distal axons degenerate after an injury to clear the way for proximal axonal regeneration.

CLINICAL STUDIES

Volunteers and doctors who participate in clinical trials help make new therapies a reality. Clinical trials are carefully designed research studies in humans that evaluate the safety and efficacy of an investigational therapy.

SUMMARY

NTX-001 is an investigational product intended for use with standard suture repair of a severed nerve, intended to accelerate the often slow and incomplete return of function. It is in Phase 3 development and is not FDA-approved.

NTX-002 is a separate investigational device in preclinical development and is not FDA-approved or cleared. The two are not approved for use together, and no clinical benefit of combined use has been demonstrated.

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